From target to candidate — integrated CRO services in antibody discovery, protein science, antibody engineering, and project management
QenovaBio is a biopharmaceutical CRO providing integrated R&D services to pharma companies, biotech firms, and research institutions worldwide. Our platform spans antibody discovery, protein science, antibody engineering, and project management — delivering customized solutions across the full antibody drug development pipeline.
From antigen design and screening through antibody generation and activity validation, we operate a closed, end-to-end workflow — ensuring standardized execution, reproducible data, and controlled project outcomes.
Our mature technology platform, standardized processes, and professional project management shorten timelines, reduce R&D risk, and improve success rates — helping clients accelerate drug development and translational research.
Milestone tracking, dynamic risk assessment, and full data traceability keep every CRO project on schedule and under control from kickoff to delivery.
Hybridoma, single B-cell sorting, and VHH nanobody platforms in one integrated service — tailored to your target type and application for rapid generation of high-affinity, high-specificity candidates.
Sequence analysis, molecular modeling, and rational design power our humanization, affinity maturation, bispecific construction, and Fc engineering services — systematically improving candidate developability.
Mammalian, prokaryotic, and insect cell expression systems cover the full workflow from protein production to functional and structural characterization, with standardized QC ensuring batch consistency.
Standardized Service Workflow
From target validation to lead optimization and preclinical research, our team is ready to recommend the right solution and accelerate your R&D programs.
Multiple expression systems and comprehensive characterization — from target protein production to functional analysis — delivering high-quality protein support for antibody development and downstream applications.
Get Quote →QenovaBio's protein science platform covers the full workflow from target protein production to functional and structural characterization. Mammalian, prokaryotic, and insect cell expression systems are available, with purification strategies optimized to each protein's properties.
Characterization capabilities include physicochemical profiling, conformational stability, and binding kinetics. Protein engineering and tag design services are offered to improve expression, solubility, and activity. Standardized processes and stringent QC ensure batch-to-batch consistency for antibody development, functional research, and structural biology.

Preferred for glycosylated therapeutic proteins; delivers high biological activity for preclinical applications.
Cost-effective and fast; ideal for small, non-glycosylated proteins requiring large-scale production or rapid functional validation.
Combines efficient expression with eukaryotic folding; ideal for complex proteins and VLP production requiring stable activity.
Multi-System Expression — mammalian, prokaryotic, and insect cell options with flexible, customizable strategies
Purification Development — protein-specific workflows delivering high-purity, high-activity targets
Comprehensive Characterization — physicochemical properties, conformational stability, and binding kinetics
Standardized QC — batch-to-batch consistency for reproducible, reliable data
Hybridoma, single B-cell sorting, and VHH nanobody platforms combined — customized to your target and application for rapid generation of high-affinity, high-specificity candidates.
Get Quote →QenovaBio's antibody discovery platform integrates hybridoma, single B-cell sorting, and VHH nanobody routes into one seamless offering — delivering high-affinity, high-specificity candidates tailored to your target and application.
QenovaBio's hybridoma workflow covers animal immunization, cell fusion, positive clone screening, and subclone stabilization. High-throughput screening combined with molecular sequencing resolves variable region sequences, supporting recombinant expression, engineering, and IP establishment. Suited for highly specific monoclonal antibodies with scalability for both research and industrial use.
FACS-based isolation of antigen-specific B cells at single-cell resolution preserves native heavy/light chain pairing, maintaining intrinsic affinity and specificity. Paired with in vitro culture and high-throughput screening, this approach shortens timelines and improves functional hit rates — applicable across mouse, rabbit, and humanized mouse species.
Built on camelid immunization, our VHH platform uses phage or yeast display to generate highly diverse libraries for efficient screening against conformational or cryptic epitopes. The resulting nanobodies offer small size, high stability, and strong tissue penetration — ideal for therapeutic, diagnostic, and structural biology use.

Multi-Route Integration — hybridoma, single B-cell sorting, and VHH nanobody under one platform
High-Precision FACS Sorting — native heavy/light chain pairing preserves intrinsic affinity and specificity
Multi-Species Support — rabbit, mouse, camelid, and other host species
Sequence IP Delivery — variable region sequences provided to support patent filing
Sequence data, structural modeling, and rational design drive our humanization, affinity maturation, Fc engineering, and format conversion services — improving developability and clinical potential of your candidates.
Get Quote →QenovaBio's antibody engineering platform uses sequence and structural data with molecular modeling to drive directed CDR and framework modifications — achieving affinity maturation, specificity tuning, and stability improvement. Supported formats include humanized antibodies, Fc-engineered variants, Fab, scFv, and bispecifics. High-throughput expression and screening identify the best candidates by developability, and the platform integrates seamlessly with upstream discovery for end-to-end drug development support.

Directed CDR Engineering — targeted modifications for affinity maturation, specificity, and stability
Multi-Species Humanization — mouse, rabbit, and camelid antibodies humanized with ≥80% affinity retention
Multi-Format Construction — Fab, scFv, and bispecific antibody building and expression
Fc Engineering — half-life extension, ADCC enhancement, and FcRn optimization
High-Throughput Validation — parallel functional and biophysical screening of engineered molecules
Seamless Integration — fully connected to upstream discovery for end-to-end pipeline support
Standardized workflows, milestone management, and dynamic risk assessment ensure efficient, fully traceable execution from project kickoff to final delivery.
Get Quote →QenovaBio's project management framework governs the full lifecycle of antibody discovery and CRO services. At initiation, we assess technical feasibility and define a clear research plan with milestones and delivery standards.
Throughout execution, standardized workflows and regular progress updates keep critical nodes — immunization, screening, and candidate confirmation — on track with continuous risk monitoring.
A comprehensive data recording and documentation system ensures full experimental traceability and standardized reporting. The framework scales to projects of any complexity, improving efficiency and reducing risk without compromising scientific rigor.

Milestone Management — defined critical nodes and delivery standards for phased, controlled progression
Regular Progress Updates — timely status reporting with prompt responses to change requests
Dynamic Risk Assessment — continuous monitoring at immunization, screening, and candidate confirmation nodes
Data Traceability — full experimental archive with standardized documentation for complete auditability
Four core platforms — antigen design & immunization, antibody screening, engineering optimization, and protein characterization

We offer a versatile antigen design and immunization platform that goes beyond conventional protein immunization. Multiple strategies — DNA, mRNA, cell-based, and VLP immunization — can be flexibly deployed to maximize immunogenicity and improve the probability of generating high-quality antibodies.
For complex membrane proteins, conformational antigens, and highly conserved targets, we have developed VLP-display formats for over 10 proteins to enhance native-conformation recognition. Through established partnerships, we also support genetically engineered mouse models (knockout and humanized) for targets with high homology or strong immune tolerance.

Our multi-technology screening system selects the optimal strategy for each target type rather than defaulting to a single platform.
For membrane proteins, hybridoma technology preserves native conformational recognition. For nanobodies or high-affinity candidates, phage display enables large-library screening and rapid affinity optimization. Single B-cell and yeast display are also available. This integrated approach balances screening efficiency, diversity, and hit rate to maximize antibody quality and developability.

Our engineering team has deep expertise in antibody humanization, using established CDR grafting protocols to reduce immunogenicity while preserving affinity and specificity for accelerated clinical translation.
Affinity maturation is supported by phage and yeast display directed evolution platforms for high-throughput mutation screening. We are also integrating AI and machine learning tools for structure prediction, mutation design, and sequence optimization to further improve development efficiency.

Our protein characterization platform provides multi-dimensional quality assessment and functional analysis of antibodies and antigens. Core capabilities include binding kinetics, affinity determination, specificity analysis, and developability assessment.
SPR/BLI, biophysical analysis, and stability methods are integrated to evaluate stability, manufacturability, and developability risk. This platform delivers the data needed to guide screening decisions and engineering optimization, improving downstream development success rates.
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