Full-Spectrum Antibody & Protein Research Services

From target to candidate — integrated CRO services in antibody discovery, protein science, antibody engineering, and project management

QenovaBio is a biopharmaceutical CRO providing integrated R&D services to pharma companies, biotech firms, and research institutions worldwide. Our platform spans antibody discovery, protein science, antibody engineering, and project management — delivering customized solutions across the full antibody drug development pipeline.

From antigen design and screening through antibody generation and activity validation, we operate a closed, end-to-end workflow — ensuring standardized execution, reproducible data, and controlled project outcomes.

Our mature technology platform, standardized processes, and professional project management shorten timelines, reduce R&D risk, and improve success rates — helping clients accelerate drug development and translational research.

QenovaBio
Project Management

Milestone tracking, dynamic risk assessment, and full data traceability keep every CRO project on schedule and under control from kickoff to delivery.

Milestone Management Risk Assessment Progress Tracking Data Traceability
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Antibody Discovery

Hybridoma, single B-cell sorting, and VHH nanobody platforms in one integrated service — tailored to your target type and application for rapid generation of high-affinity, high-specificity candidates.

Hybridoma Technology Single B-Cell Sorting VHH Nanobody Multi-Species Support
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Antibody Engineering

Sequence analysis, molecular modeling, and rational design power our humanization, affinity maturation, bispecific construction, and Fc engineering services — systematically improving candidate developability.

Humanization Affinity Maturation Bispecific Antibodies Fc Engineering
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Protein Science

Mammalian, prokaryotic, and insect cell expression systems cover the full workflow from protein production to functional and structural characterization, with standardized QC ensuring batch consistency.

Mammalian Cell Prokaryotic System Insect Cell Protein Characterization
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Standardized Service Workflow

Requirements Discussion
1–2 Days
Proposal Development
3–5 Days
Experimental Execution
Per Milestone
Data Analysis
1–2 Weeks
Deliverable Handoff
1 Week

We Look Forward to Collaborating with You

From target validation to lead optimization and preclinical research, our team is ready to recommend the right solution and accelerate your R&D programs.

Address Room 602, 6/F, Kaiyue Commercial Building, No. 2C, Argyle Street, Mongkok Kowloon, Hong Kong
Email info@qenovabio.com
Business Hours Monday – Friday, 09:00 – 18:00

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Protein Science

Multiple expression systems and comprehensive characterization — from target protein production to functional analysis — delivering high-quality protein support for antibody development and downstream applications.

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Service Overview

QenovaBio's protein science platform covers the full workflow from target protein production to functional and structural characterization. Mammalian, prokaryotic, and insect cell expression systems are available, with purification strategies optimized to each protein's properties.

Characterization capabilities include physicochemical profiling, conformational stability, and binding kinetics. Protein engineering and tag design services are offered to improve expression, solubility, and activity. Standardized processes and stringent QC ensure batch-to-batch consistency for antibody development, functional research, and structural biology.

Protein Science

Expression System Selection

Mammalian Cell System (CHO / HEK293)

Preferred for glycosylated therapeutic proteins; delivers high biological activity for preclinical applications.

Prokaryotic System

Cost-effective and fast; ideal for small, non-glycosylated proteins requiring large-scale production or rapid functional validation.

Insect Cell System

Combines efficient expression with eukaryotic folding; ideal for complex proteins and VLP production requiring stable activity.

Key Features

Multi-System Expression — mammalian, prokaryotic, and insect cell options with flexible, customizable strategies

Purification Development — protein-specific workflows delivering high-purity, high-activity targets

Comprehensive Characterization — physicochemical properties, conformational stability, and binding kinetics

Standardized QC — batch-to-batch consistency for reproducible, reliable data

Ready to start your protein science project?

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Antibody Discovery

Hybridoma, single B-cell sorting, and VHH nanobody platforms combined — customized to your target and application for rapid generation of high-affinity, high-specificity candidates.

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Service Overview

QenovaBio's antibody discovery platform integrates hybridoma, single B-cell sorting, and VHH nanobody routes into one seamless offering — delivering high-affinity, high-specificity candidates tailored to your target and application.

QenovaBio's hybridoma workflow covers animal immunization, cell fusion, positive clone screening, and subclone stabilization. High-throughput screening combined with molecular sequencing resolves variable region sequences, supporting recombinant expression, engineering, and IP establishment. Suited for highly specific monoclonal antibodies with scalability for both research and industrial use.

FACS-based isolation of antigen-specific B cells at single-cell resolution preserves native heavy/light chain pairing, maintaining intrinsic affinity and specificity. Paired with in vitro culture and high-throughput screening, this approach shortens timelines and improves functional hit rates — applicable across mouse, rabbit, and humanized mouse species.

Built on camelid immunization, our VHH platform uses phage or yeast display to generate highly diverse libraries for efficient screening against conformational or cryptic epitopes. The resulting nanobodies offer small size, high stability, and strong tissue penetration — ideal for therapeutic, diagnostic, and structural biology use.

Antibody Discovery

Key Features

Multi-Route Integration — hybridoma, single B-cell sorting, and VHH nanobody under one platform

High-Precision FACS Sorting — native heavy/light chain pairing preserves intrinsic affinity and specificity

Multi-Species Support — rabbit, mouse, camelid, and other host species

Sequence IP Delivery — variable region sequences provided to support patent filing

Ready to start your antibody discovery project?

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Antibody Engineering

Sequence data, structural modeling, and rational design drive our humanization, affinity maturation, Fc engineering, and format conversion services — improving developability and clinical potential of your candidates.

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Service Overview

QenovaBio's antibody engineering platform uses sequence and structural data with molecular modeling to drive directed CDR and framework modifications — achieving affinity maturation, specificity tuning, and stability improvement. Supported formats include humanized antibodies, Fc-engineered variants, Fab, scFv, and bispecifics. High-throughput expression and screening identify the best candidates by developability, and the platform integrates seamlessly with upstream discovery for end-to-end drug development support.

Antibody Engineering

Key Features

Directed CDR Engineering — targeted modifications for affinity maturation, specificity, and stability

Multi-Species Humanization — mouse, rabbit, and camelid antibodies humanized with ≥80% affinity retention

Multi-Format Construction — Fab, scFv, and bispecific antibody building and expression

Fc Engineering — half-life extension, ADCC enhancement, and FcRn optimization

High-Throughput Validation — parallel functional and biophysical screening of engineered molecules

Seamless Integration — fully connected to upstream discovery for end-to-end pipeline support

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Project Management

Standardized workflows, milestone management, and dynamic risk assessment ensure efficient, fully traceable execution from project kickoff to final delivery.

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Service Overview

QenovaBio's project management framework governs the full lifecycle of antibody discovery and CRO services. At initiation, we assess technical feasibility and define a clear research plan with milestones and delivery standards.

Throughout execution, standardized workflows and regular progress updates keep critical nodes — immunization, screening, and candidate confirmation — on track with continuous risk monitoring.

A comprehensive data recording and documentation system ensures full experimental traceability and standardized reporting. The framework scales to projects of any complexity, improving efficiency and reducing risk without compromising scientific rigor.

Project Management

Management Highlights

Milestone Management — defined critical nodes and delivery standards for phased, controlled progression

Regular Progress Updates — timely status reporting with prompt responses to change requests

Dynamic Risk Assessment — continuous monitoring at immunization, screening, and candidate confirmation nodes

Data Traceability — full experimental archive with standardized documentation for complete auditability

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Cutting-Edge Technology Driving Research Innovation

Four core platforms — antigen design & immunization, antibody screening, engineering optimization, and protein characterization

Quick Navigation
Antigen Design
Antibody Screening
Antibody Engineering
Protein Characterization
Antigen Design and Immunization Strategy

Antigen Design & Immunization Strategy

We offer a versatile antigen design and immunization platform that goes beyond conventional protein immunization. Multiple strategies — DNA, mRNA, cell-based, and VLP immunization — can be flexibly deployed to maximize immunogenicity and improve the probability of generating high-quality antibodies.

For complex membrane proteins, conformational antigens, and highly conserved targets, we have developed VLP-display formats for over 10 proteins to enhance native-conformation recognition. Through established partnerships, we also support genetically engineered mouse models (knockout and humanized) for targets with high homology or strong immune tolerance.

DNA Immunization mRNA Immunization VLP Display Cell-Based Immunization Transgenic Mice
Antibody Screening Platform

Antibody Screening

Our multi-technology screening system selects the optimal strategy for each target type rather than defaulting to a single platform.

For membrane proteins, hybridoma technology preserves native conformational recognition. For nanobodies or high-affinity candidates, phage display enables large-library screening and rapid affinity optimization. Single B-cell and yeast display are also available. This integrated approach balances screening efficiency, diversity, and hit rate to maximize antibody quality and developability.

Hybridoma Technology Phage Display Single B-Cell Screening Yeast Display Multi-Technology Integration
Antibody Engineering and Optimization

Antibody Engineering & Optimization

Our engineering team has deep expertise in antibody humanization, using established CDR grafting protocols to reduce immunogenicity while preserving affinity and specificity for accelerated clinical translation.

Affinity maturation is supported by phage and yeast display directed evolution platforms for high-throughput mutation screening. We are also integrating AI and machine learning tools for structure prediction, mutation design, and sequence optimization to further improve development efficiency.

CDR Grafting Humanization Affinity Maturation Phage / Yeast Display AI-Assisted Design
Protein Characterization Platform

Protein Characterization

Our protein characterization platform provides multi-dimensional quality assessment and functional analysis of antibodies and antigens. Core capabilities include binding kinetics, affinity determination, specificity analysis, and developability assessment.

SPR/BLI, biophysical analysis, and stability methods are integrated to evaluate stability, manufacturability, and developability risk. This platform delivers the data needed to guide screening decisions and engineering optimization, improving downstream development success rates.

SPR / BLI Binding Kinetics Affinity Analysis Developability Assessment Stability Analysis

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